Assessment of serum prolactin, prothrombin time and activated partial thromboplastin time in post-menopausal women
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria.
Research Article
World Journal of Advanced Pharmaceutical and Life Sciences, 2026, 10(01), 009-013.
Article DOI: 10.53346/wjapls.2026.10.1.0011
Publication history:
Received on 11 February 2026; revised on 20 March 2026; accepted on 23 March 2026
Abstract:
Post-menopause is described as the period following twelve consecutive months no menstruation, indicating the end of the reproductive phase and ovarian failure, followed by a reduction in estrogen and several physical and psychological changes. This study aimed to determine the serum prolactin and some hematological values in post-menopausal women. Blood samples were drawn in 70 women (aged 53-80 years) who have not menstruated for more than 12 consecutive months and 30 control subjects who were apparently healthy aged 20–47 years. These women attained natural menopause and were not taken any hormonal intervention. Post-menopausal women had significantly lower prolactin levels (12.121 ± 4.991 ng/ml) compared to apparently healthy women (21.916 ± 12.416 ng/ml; p <0.001). The mean value of activated partial thromboplastin time (APTT) significantly increased (34.388 ± 2.751 second)) compared to control subjects (31.296 ± 3.291 second; p=0.044). There were significant lower levels of prolactin and higher levels of activated partial thromboplastin time in post-menopausal women.
Keywords:
Prolactin; Post-menopausal; Women; Prothrombin time; Thromboplastin
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