The role of bioimpedancemetry in optimizing antihypertensive therapy in patients with high peripheral resistance
Department of Cardiology, Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan.
Research Article
World Journal of Advanced Pharmaceutical and Life Sciences, 2024, 07(02), 033-038.
Article DOI: 10.53346/wjapls.2024.7.2.0041
Publication history:
Received on 14 November 2024; revised on 23 December 2024; accepted on 26 December 2024
Abstract:
Background: Hypertension remains a leading global health concern, particularly in patients with high peripheral resistance, where therapeutic optimization poses a significant challenge. Bioimpedancemetry offers a novel approach to individualize antihypertensive therapy by providing insights into vascular resistance and fluid distribution. This study aimed to evaluate the role of bioimpedancemetry in optimizing antihypertensive therapy in patients with high peripheral resistance.
Methods: A total of 62 patients with hypertension (29–60 years, mean age 48.75 ± 1.6 years; 30 women) were included in the study. Bioimpedancemetry was employed to assess vascular resistance and fluid balance at baseline and during therapy. Based on the findings, antihypertensive therapy was tailored to individual needs. Blood pressure control, peripheral resistance, and clinical outcomes were evaluated over six months.
Results: Bioimpedancemetry-guided therapy resulted in a significant reduction in mean arterial blood pressure (p < 0.05) and peripheral resistance (p < 0.01) compared to standard therapy. Women demonstrated greater improvement in vascular resistance parameters (p < 0.05) than men. Additionally, therapy adjustments based on bioimpedance data improved patient adherence and overall therapeutic efficacy. No adverse effects related to therapy adjustments were reported.
Conclusion: The integration of bioimpedancemetry in managing patients with hypertension and high peripheral resistance significantly enhances therapeutic outcomes by enabling personalized treatment strategies. This method holds promise for broader clinical application in hypertension management.
Keywords:
Bioimpedancemetry; Hypertension; Peripheral resistance; Antihypertensive therapy; Personalized medicine
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