Haematological, hepatic and oxidative stress indices of female Wistar rats treated with ethanolic leaf extract of Spondias mombin
1 Department of Biochemistry, Faculty of Basic Sciences, College of Health Science, Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State, Nigeria.
2 Department of Medical Laboratory Science, Faculty of Basic Sciences, College of Health Science, Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State, Nigeria.
3 Department of Chemistry, Isaac Jasper Boro College of Education, Sagbama, Bayelsa State, Nigeria.
Research Article
World Journal of Advanced Pharmaceutical and Medical Research, 2022, 03(02), 010–018.
Article DOI: 10.53346/wjapmr.2022.3.2.0037
Publication history:
Received on 25 September 2022; revised on 31 October 2022; accepted on 02 November 2022
Abstract:
Local population utilize the medicinal herb Spondias mombin to cure a variety of illnesses. In this study, the toxicity of an ethanolic leaf extract of Spondias mombin was investigated using haematological, hepatic, and oxidative stress parameters in female wistar rats. Three sets of five rats each were formed from fifteen (15) female rats weighing 117g to 210g. Group A served as control, Group B received 100mg/kg, and Group C received 200mg/kg body weight of ethanolic leaf extract. The extract was administered orally for fourteen (14) days. At the completion of the treatment, blood and tissue samples were collected for haematological, hepatic enzymes and histological examination. The result showed no significant (p>0.05) difference in body weight of rats. However, a significant (p<0.05) reduction was observed in the organ (liver) weight of rats treated with the extract. Packed cell volume, haemoglobin concentration, Red Blood Cell and white blood cell values were significantly (p<0.05) increased after 14days of treatment with ethanolic leaf extract Spondias mombins. Liver enzymes aspartate transaminase and alanine transaminase showed no significantly changes when compared with the control. However, alkaline phosphatase was significantly increased in the extract treated female rats. There was a significant (p<0.05) increase in superoxide dismutase and a significant (p<0.05) decrease in malondialdehyde levels compared with the control. Rats administered with the plant extract showed no histological alterations in the liver sections. This result confirms the haematinic potential of Spondias mombin plant, and prolonged and high dosages may cause liver damage.
Keywords:
Haematological Indices; Liver Enzymes; Oxidative stress markers; Spondias mombin
Full text article in PDF:
Copyright information:
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0