Hematological and kidney-functional analysis of acetic acid-induced inflammatory rats administered flavonoid-rich fraction of Ficus sur
Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria.
Research Article
World Journal of Advanced Pharmaceutical and Medical Research, 2021, 01(01), 024–034.
Article DOI: 10.53346/wjapmr.2021.1.1.0016
Publication history:
Received on 09 May 2021; revised on 15 June 2021; accepted on 17 June 2021
Abstract:
Background and aims: Unregulated inflammation causes dysfunctional immune system and could consequently lead to blood disorders due to impaired hematopoietic process, and also destruction of important organs as a result of autoimmunity. In this study, flavonoid-rich fraction of Ficus sur (FRFFS) is investigated for its effects on hematological parameters and renal metabolites in inflammation-induced rats.
Materials and methods: Inflammation was induced in Wistar rats of average weight of 112.60 ± 0.75 g by successive oral administration of 6% at (20 ml/kg), 3% at (15 ml/kg) and 6% at (10 ml/kg) acetic acid for one week. Experimental animals were orally administered various doses of FRFFS; 15 mg/kg, 30 mg/kg, 60 mg/kg and 120 mg/kg for two weeks. Blood and kidney samples were collected for hematological parameters and kidney functional assays respectively, and data were analyzed using SPSS version 20.
Results: FRFFS significantly (p < 0.05) increased pack cell volume, hemoglobin, red blood cells and platelets, and significantly decreased white blood cells, most especially at 120 mg/kg and 60 mg/kg doses. Similarly, it significantly increased kidney urea and creatinine concentrations.
Conclusion: Sequel to these findings, it is inferred that FRFFS could be a potential natural therapy for hematological and renal disorders.
Keywords:
Flavonoid-rich fraction; Hematopoietic; Inflammation; Metabolites; and Renal disorders
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