Antioxidant activities of an iridoid-rich beverage containing noni juice, cornelian cherries, and olive extract in vitro and in human volunteers
1 Research and Development, Partner.Co, 36 North 1100 East, Suite C, American Fork, Utah 84003, USA.
2 Research and Development, Partner.Co, American Fork, Utah, USA.
Research Article
World Journal of Advanced Pharmaceutical and Medical Research, 2024, 07(01), 001–008.
Article DOI: 10.53346/wjapmr.2024.7.1.0040
Publication history:
Received on 04 June 2024; revised on 14 July 2024; accepted on 17 July 2024
Abstract:
Plant-based foods are dietary sources of antioxidant compounds that are helpful in preventing or alleviating oxidative stress. Iridoids are a class of secondary plant metabolites with antioxidant activities. An iridoid-rich beverage, Tahitian Noni® Max (Max), that contains Morinda citrifolia (noni) juice, Cornus mas (cornelian cherry) fruit purée, and Olea europaea (olive) extract was evaluated for antioxidant activity in vitro and in healthy nonsmoking young adult volunteers. Iridoid analyses were also performed via high performance liquid chromatography (HPLC) with samples of Max to confirm the presence of deacetylasperulosidic acid, asperulosidic acid, scandoside, loganic acid, and oleuropein. The oxygen radical absorbance capacity (ORAC) assay results reveal that Max possesses notable antioxidant potential, with four times more in vitro antioxidant potential than pasteurized blood orange juice. In the human trial, all participants in the Max group experienced increases in erythrocyte and plasma antioxidant activities within 40 minutes of ingestion. Further, the average erythrocyte antioxidant activity of this group increased approximately 28 times more, and just over 49 times more for average plasma antioxidant activity, than those in a blood orange juice control group (P < 0.001). The findings of the current study indicates that Max is a significant dietary source of iridoids and improves the antioxidant activity of components of the blood within 40 minutes of ingestion.
Keywords:
Morinda citrifolia; Cornus mas; Antioxidant; Iridoids
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