Comparison effect of two prophylactic protocols on prevention, complications biological and bone resorption
1 Magister Pharmacological Sciences, National University of Colombia, UniCIEO, Carrera 71 No 127 A 41. Bogotá DC, Colombia.
2 University of Veracruzana, Mexico, Fundation University UniCIEO. Bogotá Colombia.
3 Magister Sciences. National University of Colombia. Bogotá DC. Colombia.
Research Article
World Journal of Advanced Pharmaceutical and Medical Research, 2021, 01(01), 035–040.
Article DOI: 10.53346/wjapmr.2021.1.1.0015
Publication history:
Received on 15 April 2021; revised on 21 May 2021; accepted on 24 May 2021
Abstract:
Objective: Compare effect of two prophylactic protocols on prevention of biology complications and on bone resorption, before and three-month post-surgery of oral implants.
Method: Clinical, observational, longitudinal study. Approved by the Institutional Ethics Committee. The sample 29 patients signed the informed consent to participate in this study were distributed into two groups: Group 1: with oral mucosa smears culture and antibiogram to select effective prophylaxis antimicrobial and therapy. Urinary levels deoxypyridinoline (DPD). Bone height measured before and three months after oral implant surgery. Group 2: Amoxicillin prophylaxis, bone heights before and three months after oral implant surgery. The two groups underwent clinical examination 8 and 30 days after surgery to assess early complications.
Results: The average age for both sexes in both groups; (women 53.53 year; men 54.58 year). Group 1: 17 patients: 6 male patients (35.3%) and 11 female patients (65.7%). Bacterium identified: Streptococcus anginosus (8 patients), Porphyromonas gingivalis (5 patients) and Prevotella intermedia (4 patients). Antibiotics prescribed according to degree of sensitivity: Amoxicillin, Clindamycin, and Cephalexin and Cephadroxyl 30 minutes before surgery. Urinary DPD Female 8.82 nM DPD/mM, and male 5.53 nM DPD/mM .The prevalence of infection related complications during 30 days after surgery was 0%.Group 2:6 male patients and 6 female patients Prophylaxis Amoxicillin (2 g) 30 minutes before surgery. Bone height reabsorption during the three months of observation was 1.693 mm (p >0.05). The prevalence of infection related complications during 30 days after surgery was 50%. The difference between groups for frequency of complications was significant (p = 0.0003). Bone height difference between groups was not significant.
Conclusion: The use of antibiotic prophylactic protocol based on the oral mucosa smears and antibiogram to select effective antimicrobial, prevents the presence of early biology complications and reduces bone resorption.
Keywords:
Antibiogram; Antibiotic prophylaxis; Infections; Bone resorption
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