Solid lipid nanoparticles of antifungal drugs: A comprehensive review of development, characterization and evaluation
1 Department of Pharmaceutics, Nargund College of Pharmacy, Bangalore -85, Karnataka, Bharat.
2 Department of Pharmaceutics, Nitte College of Pharmaceutical Sciences, Bangalore-64, Karnataka, Bharat.
3 Department of Pharmaceutics, Government College of Pharmacy, Bangalore-27, Karnataka, Bharat.
4 Department of Pharmacology, Nargund College of pharmacy, Bangalore -85, Karnataka, Bharat.
5 Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Bangalore -85, Karnataka, Bharat.
Review
World Journal of Advanced Science and Technology, 2025, 08(02), 009-019.
Article DOI: 10.53346/wjast.2025.8.2.0021
Publication history:
Received on 07 July 2025; revised on 28 September 2025; accepted on 01 October 2025
Abstract:
Solid lipid nanoparticles (SLNs) were introduced in 1991, as a replacement for traditional colloidal transporters like emulsions, liposomes, and polymers. SLNs overcome limitations of classical structures and offer effective drug distribution. This review discusses the SLN methods for production, characterization, evaluation, in vitro studies, ex vivo studies and in vivo studies. SLNs are colloidal carriers that provide effective release, identification, and guided drug distribution. The article focuses on minimizing harmful impacts through developed manufacturing methods like homogenization and solvent evaporation. The study explores the potential of SLNs as a novel medication system using advanced analytical techniques like electron microscopy, dynamic light scattering. SLNs are incorporated in gel for easy topical application and antifungal activity. Preparation and evaluation of SLN loaded gels is also discussed.
Keywords:
Solid lipid nanoparticles; Gel; In vitro study; Ex vivo permeation study; In vivo animal models
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0