The expression of Cox-2 and Cyclin D1 with clinicopathological characteristics in oral epithelial dysplasia: A retrospective study
Department of Oral Pathology, College of Dentistry, Mustansiriyah University, Baghdad, Iraq.
Research Article
World Journal of Biological and Pharmaceutical Research, 2023, 05(02), 031–037.
Article DOI: 10.53346/wjbpr.2023.5.2.0071
Publication history:
Received on 24 October 2023; revised on 24 December 2023; accepted on 27 December 2023
Abstract:
Background: Oral mucosal cancers are often preceded by potentially malignant diseases that may exhibit diverse morphological and histological alterations. The expression of COX 2 has been related to tumor vascularization, dissemination, and survival in oral cancer studies. High levels of cyclin D1 expression to precancerous lesions and oral malignancies. This study was designed to evaluate and compare the immunohistochemical expression of the above-mentioned markers.
Materials and Methods: 50 retrospective formalin fixed-paraffin embedded histopathologically confirmed blocks of oral epithelial dysplasia. Immunohistochemical staining was performed using monoclonal antibodies against COX-2 and Cyclin D1. Using a standard camera, photomicrographs of the slides were taken.
Results: No significant difference in the age distribution of the patients studied, as well as age pivoting at the fifth and sixth decades with mean and standard deviation (53.36 2.63). There was no significant difference in gender among the studied patients. Furthermore, there was a highly significant difference in grade distribution.
Conclusions: The COX-2 and Cyclin D1 markers may assist in diagnosing oral epithelial dysplasia based on severity. It's easy to gather image-analytic data on the stained tissue specimens.
Keywords:
Epithelial Dysplasia; Malignancy; Cox-2; Cyclin D1; Immunohistochemistry
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