The role of 5´-nucleotidases in function of immune system cells
CJsC "Center of Haematology named after prof. R.H. Yeolyan" MH RA.
Research Article
World Journal of Biological and Pharmaceutical Research, 2022, 02(01), 005–009.
Article DOI: 10.53346/wjbpr.2022.2.1.0133
Publication history:
Received on 15 November 2021; revised on 24 January 2022; accepted on 26 January 2022
Abstract:
Disorder of purine metabolism, in particular the activity of 5'-nucleotidase, which is one of the key enzymes of the purine cycle, leads to functional inferiority of cells of the immune system. 5'-nucleotidase is considered a marker of the functional maturity of lymphocytes. In our opinion, research of activity of the enzyme at various immunodeficiency conditions can serve not only as additional prognostic criteria but also be essential help both at tactics choice and at an estimation of efficiency of therapy with purine analogs.
Keywords:
Purine nucleotides; 5´-nucleotidase; Immune system; Lymphoproliferative diseases
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