Perspectives of using of somatic cells fusion process in some aspects of car¬cino¬ge-nesis
33, Vasha-Pshavela ave., Tbilisi, 0177, Georgia.
Review
World Journal of Biological and Pharmaceutical Research, 2022, 03(02), 024-027.
Article DOI: 10.53346/wjbpr.2022.3.2.0040
Publication history:
Received on 20 October 2022; revised on 08 December 2022; accepted on 10 December 2022
Abstract:
Normal somatic cells sensitive to carcinogenic effects and capable of proliferation form firstly a binuclear cells (dikaryons) and then hybrid cells (mononucleated synkaryons) by means of fusion with another cells of the same organism, in particular with differentiated and non-differentiated cells of corresponding tissue or with cells capable to migrate.
In all probability, during the perforation of the plasma membrane, i.e., after the formation of pores, induced by different carcinogenic (and noncarcinogenic) agents and factors, the total negative charge of plasma membrane changes (decreases) and the cells develop the ability to come closer to each other, which will probably be the prerequisite to a fusion process. On the other hand, it is not excluded that perforation can assist the fusion of only neighboring cells.
Initially, a set of chromosomes in a precancerous cell retains, even for a short time, the condition of tetraploidy. Because of cell fusion generates tetraploidy, it potentially might cause chromosomal instability.
The article emphasizes a possibility of using the fusion process in different aspects of carcinogenesis (therapy, prevention, etc.).
Keywords:
Fusogeny; Dikaryons; Synkarions; Malignization.
Full text article in PDF:
Copyright information:
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0