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Estimation of terbinafine HCL by spectophotometric analysis with Tpooo, Nb12br and WFB

R Mrutyunjaya Rao 1, * and CSP Sastry 2

1 SRKR Engineering College, Chinna Ammiram, Bhimavaram.
2 Foods and Drugs Laboratories, Department of Organic Chemistry Foods, Drugs and Water, Andhra University, Visakhapatnam-530003, India.
 
Research Article
World Journal of Chemical and Pharmaceutical Sciences, 2022, 01(02), 010–016.
Article DOI: 10.53346/wjcps.2022.1.2.0034
Publication history: 
Received on 22 October 2022; revised on 10 December 2022; accepted on 12 December 2022
Abstract: 
One simple and sensitive procedure (simple spectrophotometric method) for the assay of drug Terbinafine HCl in pure form and formulations. This method involves the formation of ion-association complex between TRB and the TPOOO, NB12BR and WFB. In order to establish the optimum conditions necessary for rapid and quantitative formation of coloured product with maximum stability and sensitivity, the author performed experiments by measuring the absorbance at λmax 480nm,420nm and580nm of respective series of solutions, varying one and fixing the other parameters in each case such as type, volume and concentration of acid, organic solvent used for extraction, ratio of organic phase to aqueous phase during extraction, shaking time and temperature. The variable parameters were optimized. The results were statistically validated.
 
Keywords: 
Terbinafine hydrochloride; Spectrophotometer; TPOOO; NB12BR; WFB
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0