Synthesis, Characterization and Biological Evaluation of Two New Co(II) and Mn(II) Complexes Derived from Substituted Amino Acid Dithiocarbamate Ligands
College of Pharmacy, University of Tikrit.
Research Article
World Journal of Chemical and Pharmaceutical Sciences, 2026, 08(02), 026-038.
Article DOI: 10.53346/wjcps.2026.8.2.0019
Publication history:
Received on 08 May 2026; revised on 15 June 2026; accepted on 17 June 2026
Abstract:
Two substituted amino acid dithiocarbamate ligands were synthesized and used for the preparation of two new transition metal complexes. Potassium 4-bromophenylalanine dithiocarbamate, K[4-Br-Phe-dtc] (L1), was prepared from 4-bromophenylalanine, potassium hydroxide, and carbon disulfide. Potassium 5-methoxytryptophan dithiocarbamate, K[5-MeO-Trp-dtc] (L2), was prepared using the same approach from 5-methoxytryptophan. The ligands were reacted with cobalt(II) chloride hexahydrate and manganese(II) chloride tetrahydrate to give [Co(4-Br-Phe-dtc)₂] (C1) and [Mn(5-MeO-Trp-dtc)₂] (C2), respectively. The compounds were characterized by melting point, molar conductivity, FT-IR, UV-Vis spectroscopy, magnetic susceptibility, ¹H-NMR and antibacterial activity. FT-IR data supported coordination through the sulfur atoms of the dithiocarbamate group, while low molar conductivity values indicated non-electrolyte complexes. Magnetic and electronic spectral data suggested tetrahedral geometries around both Co(II) and Mn(II). The antibacterial results showed that complexation enhanced activity compared with the free ligands, especially against Staphylococcus aureus.
Keywords:
Dithiocarbamate; Amino Acid Ligand; Cobalt Complex; Manganese Complex; FT-IR; UV-Vis; Antibacterial Activity.
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