Hypolipidemial potentials of selected seed oils on high-fat fed adult albino rats
1 Department of Science Laboratory Technology, School of Science and Technology, Gateway Polytechnic, Saapade, Ogun State, Nigeria.
2 Department of Medical Biochemistry, Lagos State University, Ikeja campus, Lagos State, Nigeria.
3 Department of Clinical Services, Neuropsychiatric Hospital, Aro, Abeokuta, Nigeria.
4 Department of Medical Biochemistry and Pharmacology, Faculty of Pure and Applied, Sciences, Kwara State University Malete, P.M.B. 1530 Ilorin, Nigeria.
5 Department of Science Laboratory Technology, Federal Polytechnic, Ilaro, Ogun State, Nigeria.
Research Article
World Journal of Advanced Science and Technology, 2024, 06(01), 025–034.
Article DOI: 10.53346/wjast.2024.6.1.0039
Publication history:
Received on 25 May 2024; revised on 02 July 2024; accepted on 05 July 2024
Abstract:
Annually, cardiovascular diseases (CVDs) claim the lives of more than 17 million individuals. In this study, hypolipidemia potential of Persea americana, Moringa oleifera, Chrysophyllum albidum and Capsicum annuum seed oils were evaluated. Fifty adult Wistar rats of both sexes weighing between 120 and 170 g were grouped into ten, with five animals in each group. The animals were stabilized for one week prıor to the induction period. The seed oils were administered in their meal for fourteen days. Blood samples were collected through a cardıac puncture into heparinized tubes centrifuged at 5000 rpm for 10 minutes and were used for haematological and lipid profile assays. Comparatively between the analyte and control groups, the result showed no significant difference (p≥0.05) in haemoglobin (HB) with a significant increase (p≤0.05) in the packed cell volume (PCV) level of the rats. In addition, there were significant reductions in the levels of triglycerides, total cholesterol, and low‐density lipoprotein‐cholesterol. Among the male rats of the analyte and control group, there was a significant increase (p<0.5) in the level of high‐density lipoprotein‐cholesterol ın their blood samples. This study reveals that the rich essential fatty acid reported in the seed oils has hypolipidemic effect potential.
Keywords:
Cardiovascular diseases; Hypolipidemic; Packed cell volume; Seed oil; Triglycerides; Total cholesterol
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